Large differences in HbS frequencies among Kenyan and Ugandan tribes had been noted in surveys conducted by researchers other than Tony Allison. These researchers offered alternative explanations different from the malarial linkage proposed by Allison. Offer one counterargument to, or experimental test for, the following alternative hypotheses:

a.  The mutation rate is higher in certain tribes.

b.  There is a low degree of genetic mixing among tribes, so the allele rose to high frequency through inbreeding in certain tribes. How many potential evolutionary paths are there for an allele to evolve six different mutations? Seven different mutations? Ten different mutations?

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