Infection control scenario on performance of diagnostic methods

This is a paper that focuses on the Infection control scenario on performance of diagnostic methods. The paper also provides instructions to follow during the review of the data.

Infection control scenario on performance of diagnostic methods

Public Health England (PHE) have asked you to review data obtained during their investigation of a recent outbreak of Legionnaire’s disease at a small hospital near Salford.
Requirements of review
In your review of the data you should:
1.  Firstly, assess the performance of the diagnostic methods used in terms of patient management. This assessment should consider the availability of alternative assays that may have improved patient management. Do not forget to include patients with flu-like symptoms in your assessment.
2.  Secondly, among the 6 water sources from which L. pneumophila was recovered, which do you think is the most likely environmental origin of the outbreak? Explain in detail why you  this conclusion and why other potential water sources were a discount on the basis of epidemiological and fingerprinting results. This explanation should

(i) consider the likelihood of each source from a practical perspective,

(ii) summarise what each of serotyping, MLST and whole genome SNP analysis actually is and thus what the differences between them are, and

(iii) refer to the contribution of each to determining the fingerprints of L. pneumophila in this scenario.

Infection control scenario on performance of diagnostic methods

3.  Thirdly, explain why the use of UKAS standard protocols for environmental sampling is important.
4.  Fourthly, discuss the usefulness of antibiotic susceptibility testing for patient management. What the modification antibiotic regimen that ICU patients were likely to have been. This discussion requires you to access and read current guidelines for the treatment of legionellosis in the UK. Also, research studies into L. pneumophila AMR.
5.  Lastly, outline actions that you believe should have been taken during the course of the outbreak to reduce the risk of further transmission of the pathogen. Also, make recommendations in line with the UK’s Health and Safety Executive (HSE) guidelines for sustained infection control measures in the hospital to prevent a reoccurrence of the outbreak.

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